Dutasteride or Propecia?

Dutasteride or Propecia? Many male hair loss sufferers are asking themselves this question in their quest for the most powerful hair loss pill. Dutasteride and Propecia (finasteride) are both antiandrogens, so they both reduce the androgen activity in the body and happen to work by the same mode of action. Dutasteride is supposed to be more powerful from the two drugs in reducing serum levels of dihydrotestosterone (DHT) than finasteride because it is a dual 5-alpha-reductase inhibitor. It inhibits both isoforms of this enzyme that help convert testosterone into DHT and so slashes the DHT levels in the body by 95%. However, finasteride alone seems to be also very powerful as it reduces the serum levels of DHT by 90% which seems enough to stop hair loss in about 90% of male patients who take this drug regularly. Propecia (finasteride) has been first approved for treating hair loss in the US in the late 1990s and since then it has been accepted and approved as a hair loss pill in many other countries of the world.

Dutasteride, being a very similar drug to finasteride has undergone and completed phase III clinical trials as a treatment for male pattern baldness recently and results are pending. They are largely expected to show that dutasteride is a more potent hair regrowth treatment than Propecia and many believe that dutasteride will prove to be more effective especially in the frontal area of the scalp (as preliminary results indicated). The main weakness of dutasteride is the fact that it stays in human body for much longer than finasteride although preliminary study results showed its side effects to be no more severe than those from finasteride. Dutasteride is the main active substance of Avodart, the drug used to treat enlarged prostates, and you can therefore find generic Avodart in many existing online pharmacies already now. Dutasteride, though not yet approved in the US for treating hair loss, is already been prescribed by some hair restoration doctors in the US and elsewhere for such purpose to patients who do not very well respond to Propecia. Nevertheless, until dutasteride has become approved by the FDA for combating male pattern baldness, Propecia remains to be the treatment of the first choice.